A Motley Fool
Investigative Report — Saturday, May 25, 2013
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Sunday, May 26, 2013
The little shop that's putting China out of business
The little shop that's putting China out of business
A Motley Fool
Investigative Report — Saturday, May 25, 2013
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The little shop that's putting China out of business
A Motley Fool
Investigative Report — Saturday, May 25, 2013
|
||
|
The little shop that's putting China out of business
A Motley Fool
Investigative Report — Saturday, May 25, 2013
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Wednesday, May 15, 2013
ANGELINA JOLIE'S WISE DECISION
Angelina Jolie’s shocking revelation that she had a double mastectomy to prevent breast cancer has left many women wondering if they should get tested for genetic mutations that put them at high risk for the disease.
In a New York Times op-ed titled, “My Medical Choice,” Jolie, 37, reports that doctors calculated that she had an 87 percent risk for breast cancer and 50 percent risk for ovarian cancer, due to carrying a “faulty” version of the BRCA1 gene.
In the announcement—just two days after Mother’s Day—the actress explains that she didn’t want her kids to fear losing her to cancer. In 2007, Jolie’s mom, Marcheline Bertrand, died at age 56, after a 10-year battle with ovarian cancer.
“There are many women who do not know that they might be living under the shadow of cancer,” warns the Oscar-winning star, who urges women to discuss genetic testing for BRCA1 and BRCA2 gene mutations with their doctors.
Over a lifetime, one in eight women will be diagnosed with breast cancer, the most common cancer in women, other than skin cancer. This year, about 232,000 American women will be diagnosed with invasive breast cancer and nearly 40,000 will die from it, according to the American Cancer Society(ACS)
However, only about 10 percent of breast cancers stem from inherited genetic defects, says Charis Eng, MD, Ph.D., founding director of the Cleveland Clinic’s Lerner Research Institute’s Genomic Medicine Institute.
Other risk factors include age (two out of three breast cancers occur in women age 55 or older), dense breast tissue, obesity, lack of exercise, periods that start early (before age 12), and late menopause (after age 55). Women who drink two to five alcoholic beverages daily have 1.5 times the risk of those who don't drink, according to ACS.
Cancer and Your Diet: Make the Right Choices
Having a mutated BRCA1 or BRCA2 gene not only boosts a woman’s lifetime risk for breast cancer up to more than 80 percent—compared to the 12 percent risk for all women—but women who carry this defect also have an up to 50 percent risk for ovarian cancer, compared to the average risk of 0.5 percent, adds Dr. Eng.
Because ovarian cancer rarely causes early symptoms—and there’s no widely available screening test—it often goes undetected until it has spread and is difficult to treat. As a result, it is often fatal. The disease strikes about 22,000 women a year and kills 14,000, according to ACS.
Compounding the danger, women with BRCA1 or BRAC2 mutations are also likely to develop breast cancer at an earlier-than-usual age—typically before menopause—and also tend to be stricken with a highly aggressive form known as “triple-negative breast cancer.” The deadliest form of breast cancer, this subtype lacks three receptors known to fuel most breast cancers and therefore is both extremely difficult to treat and more prone to recur, reports the Triple Negative Breast Cancer Foundation.
Several other ethnic groups also have higher-than-usual rates of BRCA1 or BRCA2 mutations, including people of Norwegian, Dutch, and Icelandic ancestry. In addition, increased rates have been found among French Canadians, Dr. Eng reports. On her mom’s side, Angelina Jolie is primarily of French Canadian, Dutch, and German descent.
However, BRCA1 and BRCA2 mutations can also occur in people who are not of any of these ethnicities.
However, if the affected relatives are deceased or unwilling to be tested, then a genetic counselor can help you decide if testing is indicated. The test is performed on a blood sample, which is analyzed for all of the known mutations of the BRCA1 and BRCA2 genes.
There are also blood tests available to check for other genetic mutations linked to increased risk for breast and ovarian cancer, adds Dr. Eng. “There’s also a test that will ultimately be able to check for all ten of the genes at once, but it’s still in the research stages.”
Warning Signs of Breast Cancer
NPR reports an increase in women opting to have their breasts removed to prevent cancer. By law, insurers are required to cover reconstruction after the procedure.
A double mastectomy isn’t the only way women facing lifetime breast cancer risk as high as 87 percent due to faulty genes can protect themselves, says Dr. Eng. “Angelina Jolie made a reasonable decision and under these circumstances, many women won’t want to live in terror when breast cancer is almost inevitable."
However, adds Dr. Eng, “another option is having frequent monitoring with both mammograms and breast MRI to catch cancer as early as possible.” When caught in the early stages, breast cancer has a very high cure rate with such treatments as surgery and chemotherapy. In the later stages, new targeted treatments that act like smart bombs—attacking cancer while sparing normal cells—can sometimes help save the lives of women with advanced breast cancer.
“It’s not an incorrect choice to monitor the breasts with imaging to see if cancer actually develops,” says Dr. Eng. Since ovarian cancer has no early warning signs and can’t easily be detected with tests, prevention is more difficult. Dr. Eng notes that the standard of care for ovarian cancer prevention in women with these mutations is a hysterectomy that includes removal of the ovaries and fallopian tubes.
A study published in the Journal of the American Medical Association found that salpingo-oophorectomy—a surgery that removed only the ovaries and fallopian tubes—may reduce the risk of both breast and ovarian cancer in women who have inherited BCRA1 and BCRA2 mutations.
Women with faulty BRCA genes should discuss the best prevention strategy with a cancer specialist.
Famous Faces of Breast Cancer
In a New York Times op-ed titled, “My Medical Choice,” Jolie, 37, reports that doctors calculated that she had an 87 percent risk for breast cancer and 50 percent risk for ovarian cancer, due to carrying a “faulty” version of the BRCA1 gene.
In the announcement—just two days after Mother’s Day—the actress explains that she didn’t want her kids to fear losing her to cancer. In 2007, Jolie’s mom, Marcheline Bertrand, died at age 56, after a 10-year battle with ovarian cancer.
“There are many women who do not know that they might be living under the shadow of cancer,” warns the Oscar-winning star, who urges women to discuss genetic testing for BRCA1 and BRCA2 gene mutations with their doctors.
Blood Test Reveals Cancer Risk
“It is possible to find out through a blood test whether you are highly susceptible to breast and ovarian cancer, and then take action,” adds Jolie, who reports that her risk of breast cancer has dropped to less than 5 percent after the double mastectomy (which was followed by breast reconstruction).Over a lifetime, one in eight women will be diagnosed with breast cancer, the most common cancer in women, other than skin cancer. This year, about 232,000 American women will be diagnosed with invasive breast cancer and nearly 40,000 will die from it, according to the American Cancer Society(ACS)
However, only about 10 percent of breast cancers stem from inherited genetic defects, says Charis Eng, MD, Ph.D., founding director of the Cleveland Clinic’s Lerner Research Institute’s Genomic Medicine Institute.
Other risk factors include age (two out of three breast cancers occur in women age 55 or older), dense breast tissue, obesity, lack of exercise, periods that start early (before age 12), and late menopause (after age 55). Women who drink two to five alcoholic beverages daily have 1.5 times the risk of those who don't drink, according to ACS.
Cancer and Your Diet: Make the Right Choices
Gene Mutations Boost Cancer Risk to 80%
Known as tumor suppressor genes,BRCA1 and BRCA2 (breast cancer susceptibility gene 1 and 2 respectively), normally act as the brakes on cancer by helping to prevent cancer growth, says Dr. Eng. “If you’ve inherited a mutated copy of one of these genes, it’s like having faulty brakes on your car—you are much more likely to run into the brick wall of breast or ovarian cancer.”Having a mutated BRCA1 or BRCA2 gene not only boosts a woman’s lifetime risk for breast cancer up to more than 80 percent—compared to the 12 percent risk for all women—but women who carry this defect also have an up to 50 percent risk for ovarian cancer, compared to the average risk of 0.5 percent, adds Dr. Eng.
Because ovarian cancer rarely causes early symptoms—and there’s no widely available screening test—it often goes undetected until it has spread and is difficult to treat. As a result, it is often fatal. The disease strikes about 22,000 women a year and kills 14,000, according to ACS.
Compounding the danger, women with BRCA1 or BRAC2 mutations are also likely to develop breast cancer at an earlier-than-usual age—typically before menopause—and also tend to be stricken with a highly aggressive form known as “triple-negative breast cancer.” The deadliest form of breast cancer, this subtype lacks three receptors known to fuel most breast cancers and therefore is both extremely difficult to treat and more prone to recur, reports the Triple Negative Breast Cancer Foundation.
Certain Ethnicities Have Higher Risk
Mutations of these genes are more common among certain ethnicities and particularly in people of Ashkenazi Jewish ancestry. In one study, 2.3 percent of people of this ancestry were found to have one of three specific mutations in these genes—a frequency five times higher than in the general population.Several other ethnic groups also have higher-than-usual rates of BRCA1 or BRCA2 mutations, including people of Norwegian, Dutch, and Icelandic ancestry. In addition, increased rates have been found among French Canadians, Dr. Eng reports. On her mom’s side, Angelina Jolie is primarily of French Canadian, Dutch, and German descent.
However, BRCA1 and BRCA2 mutations can also occur in people who are not of any of these ethnicities.
Should you be checked for genetic mutations?
Dr. Eng advises consulting a genetic counselor to discuss testing if you have the potential red flags listed below. If none of them apply, you have a very low risk for a harmful mutation.- You are of Ashkenazi Jewish descent.
- You have one or more close relatives, such as your mother, sister, aunt, or grandmother, who developed breast or ovarian cancer at age 50 or younger. Having two or more relatives with ovarian cancer, regardless of the age at which it occurred, can also be a red flag, reports the National Cancer Institute. In addition, the more relatives you have with breast cancer, regardless of their age, the greater the risk for genetic defect.
- One or more of your relatives was diagnosed at any age with bilateral cancer (primary cancer in both breasts or both ovaries).
- A close relative has had triple negative breast cancer—or you have been diagnosed with this disease. Also, genetic testing is advised if you have been diagnosed with any form of breast cancer before age 50.
- A male relative was diagnosed with breast cancer.
- Two or more of your relatives have developed other types of cancer, particularly those of the thyroid, endometrium (uterine lining), stomach, or pancreas, before age 50. Some genetic mutations linked to higher risk for breast and ovarian cancer also magnify risk for other cancers, says Dr. Eng. “It’s a case of guilt by association. If there’s a pattern of early cancer in your family, it’s worth asking your doctor to refer you to a genetic counselor to see if a mutation might be responsible.”
However, if the affected relatives are deceased or unwilling to be tested, then a genetic counselor can help you decide if testing is indicated. The test is performed on a blood sample, which is analyzed for all of the known mutations of the BRCA1 and BRCA2 genes.
Is gene testing covered by health insurance?
Testing costs more than $3,000, says Dr. Eng. “Health plans will often pay what they consider to be the‘reasonable and customary’ cost of the test, or at least a portion of the cost, if the test is deemed medical necessary due to your family or medical history.”If you have no relatives with breast or ovarian cancer—and don’t have these diseases yourself—your plan is unlikely to cover any of the cost.There are also blood tests available to check for other genetic mutations linked to increased risk for breast and ovarian cancer, adds Dr. Eng. “There’s also a test that will ultimately be able to check for all ten of the genes at once, but it’s still in the research stages.”
Warning Signs of Breast Cancer
Is a double mastectomy the only option?
Jolie isn’t the only celeb who has recently undergone this procedure to prevent breast cancer. As I recently reported, Miss America contestant Allyn Rose, 24, also had elective breast removal surgery (followed by reconstruction), in the hope of avoiding the disease that claimed her mom’s life.NPR reports an increase in women opting to have their breasts removed to prevent cancer. By law, insurers are required to cover reconstruction after the procedure.
A double mastectomy isn’t the only way women facing lifetime breast cancer risk as high as 87 percent due to faulty genes can protect themselves, says Dr. Eng. “Angelina Jolie made a reasonable decision and under these circumstances, many women won’t want to live in terror when breast cancer is almost inevitable."
However, adds Dr. Eng, “another option is having frequent monitoring with both mammograms and breast MRI to catch cancer as early as possible.” When caught in the early stages, breast cancer has a very high cure rate with such treatments as surgery and chemotherapy. In the later stages, new targeted treatments that act like smart bombs—attacking cancer while sparing normal cells—can sometimes help save the lives of women with advanced breast cancer.
“It’s not an incorrect choice to monitor the breasts with imaging to see if cancer actually develops,” says Dr. Eng. Since ovarian cancer has no early warning signs and can’t easily be detected with tests, prevention is more difficult. Dr. Eng notes that the standard of care for ovarian cancer prevention in women with these mutations is a hysterectomy that includes removal of the ovaries and fallopian tubes.
A study published in the Journal of the American Medical Association found that salpingo-oophorectomy—a surgery that removed only the ovaries and fallopian tubes—may reduce the risk of both breast and ovarian cancer in women who have inherited BCRA1 and BCRA2 mutations.
Women with faulty BRCA genes should discuss the best prevention strategy with a cancer specialist.
Are BRCA mutations dangerous for men?
Having a BRCA defect increases a man’s lifetime risk for breast cancer by ten-fold, from about 1 percent to about 10 percent, according to Dr. Eng. Therefore, men with these mutations should have their breasts checked with an MRI and a physical exam. In addition, these mutations hike risk for prostate cancer, but doctors typically don’t advise any change in the screening that’s usually advised for this disease.Famous Faces of Breast Cancer
Tuesday, May 14, 2013
Have You Ever Considered Beating The Recession?
I read Theresa's blog last month and decided to feature her story in our local job report. In our phone interview she told me her amazing story. "I basically make about $6,000-$8,000 a month online. It's enough to comfortably replace my old jobs income, especially considering I only work about 10-13 hours a week from home.
Working online has been a big break for Theresa, who struggled for months going from one dead end job to another. "I lost my job shortly after the recession hit, I needed reliable income, I was not interested in the "get rich quick" scams you see all over the internet. Those are all pyramid scams or stuff where you have to sell to your friends and family. I just needed a legitimate way to earn a living for me and my family. The best part of working online is that I am always home with the kids, I save a lot of money."
"I basically make $6,000-$8,000 a month online."
-Theresa Andrews
-Theresa Andrews
I asked her about how she discovered her tight lip secret. "Honestly, it is easier than you would think, all I did was fill out a simple form to get front line access to the Home Income. I got the instructions kit and within a month I was making over $4,000 a month. The instructions are pretty simple, I am not a computer whiz, but I can use the internet. I fill forms and surf sites, I don't even have to sell anything and nobody has to buy anything. It's as easy as being on facebook."
Online giant Google, worth over 100 billion dollars is the most used search engine and internet market place. Google is the #1 internet site in the world, over 50 percent of all internet traffic flows through them everyday. Using Google and the other search engines to make money online has been a eye-opener for Theresa. There are plenty of scams on the internet claiming you can make $50,000 a month, but that is exactly what they are scams. From my conversation with Theresa, "I am making a good salary from home, which is amazing, under a year ago I was jobless in a horrible economy. I thank God every day I was blessed with these instructions and now it's my duty to pay it forward and share it with you."
Quickly, Theresa Andrews was able to use the simple Home Income Program to make it out of the recession.
A check Theresa recently received
You can also have the money deposited directly into your bank account.
You can also have the money deposited directly into your bank account.
Theresa had never shared her story before. This is the first time she's gone public.
If you would like to take advantage of the same opportunity as Theresa, here's how to get started:
Step 1
Go to this link, fill out a basic online form and hit submit at Home Income
Step 2
Follow the instructions at Home Income and set up your account.
Step 3
Deposit your earnings by check or direct bank transfer. (Making money has never been so easy. Get ready for your life to change.)
Monday, May 6, 2013
Tanzanian church blast kills one, wounds 57
DAR ES SALAAM (Reuters) - A suspected bomb attack on a new Catholic church in the northern Tanzanian town of Arusha killed at least one person and wounded dozens of others on Sunday, police said. The Vatican's ambassador to Tanzania, Archbishop Francisco Montecillo Padilla, was attending the official opening of the church when the explosion occurred, but escaped unharmed. If a bomb blast is proven, it will mark an escalation in sectarian tensions in east Africa's second biggest economy.
"Some kind of
explosion went off at the church. It is believed to have been a bomb but
we don't know what type of bomb it was," police spokesperson Advera Senso said. One person was arrested after the blast, which killed a woman and wounded 57 other people, Senso said. A Vatican embassy official said he had been in contact with Padilla. "He is personally fine," the official said.
Two Christian leaders were killed in Tanzania's
semi-autonomous, predominantly Muslim islands of Zanzibar earlier this
year and there have been attacks on Muslim leaders and mosques. Arusha
lies near the snow-capped peak of Mount Kilimanjaro in a part of
Tanzania that is predominantly Christian.
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